Actress Leslie Mann recently stopped by Jimmy Kimmel Live! and brought the house down with a hilariously relatable story about her husband, director Judd Apatow. While discussing popular Hollywood trends, Mann revealed that despite being on the popular GLP-1 weight-loss medication Ozempic, Apatow actually managed to gain weight by deliberately eating past the appetite-suppressing effects.
Ozempic, a medication widely known for suppressing appetite, typically leads to weight loss. However, Mann explained that Apatow turned his dosage into a personal challenge.
Outrunning the Feeling: “He’s on the highest dose and he likes to outrun the feeling… that Ozempic gives you to stop eating,” Mann joked.
Defying Big Pharma: Mann added that her husband takes pride in proving his appetite can’t be tamed, joking that he’s “proud of the fact that the pharmaceutical companies don’t have control over him.”
The Unexpected Result: Rather than shedding pounds, Apatow’s determination to eat through the appetite suppressant resulted in him gaining weight while on the maximum prescribed dose.
Mann’s lighthearted story struck a chord with viewers, turning a typical Hollywood conversation about weight-loss drugs into a classic comedic moment. By poking fun at his stubborn eating habits, Mann proved once again why she and Apatow remain one of comedy’s favorite long-standing couples.




